Selected Publications
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Studies of a Co(III) complex of the MMP inhibitor marimastat: a potential hypoxia activated prodrug.
T.W. Failes, C. Cullinane, C.I. Diakos, N. Yamamoto, J.G. Lyons, and T.W. Hambley,
Chemistry, A European Journal,
2006,
e-published
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XANES determination of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes.
P.D. Bonnitcha, M.D. Hall, C.K. Underwood, G.J. Foran, M. Zhang, P.J. Beale, and T.W. Hambley,
Journal of Inorganic Biochemistry,
2006,
100,
963-971
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The Fate of Platinum(II) and Platinum(IV) Anti-Cancer Agents in Cancer Cells and Tumours.
M.D. Hall, R.A. Alderden, M. Zhang, P. Beale, Z. Cai, B. Lai, A.P.J. Stampfl, and T.W. Hambley,
Journal of Structural Biology,
2006,
155,
38-44
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Models of hypoxia activated prodrugs: Co(III) complexes of hydroxamic acids.
T.W. Failes and T.W. Hambley,
Dalton Transactions,
2006,
1895-1901
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Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug.
R.A. Alderden, H.R. Mellor, S. Modok, T.W. Hambley, and R. Callaghan,
Biochemical Pharmacology,
2006,
71,
1136-1145
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The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes.
H.R. Mellor, S. Snelling, M.D. Hall, S. Modok, M. Jaffar, T.W. Hambley and R. Callaghan,
Biochemical Pharmacology,
2005,
70,
1137-1146
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Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models.
M.D. Hall, C. Martin, D.J.P. Ferguson, R.M. Phillips, T.W. Hambley, R. Callaghan,
Biochemical Pharmacology,
2004,
67,
17-30
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Platinum(IV) anticancer complexes.
M.D. Hall, R.C. Dolman and T.W. Hambley,
Metal Complexes in Tumor Diagnosis and as Anticancer Agents, Volume 42 of "Metal Ions in Biological Systems" A. Sigel and H. Sigel, editors., M. Dekker, New York & Basel,
2004,
Ch. 9,
297-322
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XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents.
M.D. Hall, G.J. Foran, M. Zhang, P.J. Beale, and T.W. Hambley,
Journal of the American Chemical Society,
2003,
125,
7524-7525
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The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.
M.D. Hall, C.T. Dillon, M. Zhang, P. Beale, Z. Cai, B. Lai, A.P.J. Stampfl, and T.W. Hambley,
Journal of Biological Inorganic Chemistry,
2003,
8,
726-732
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The interaction of metal ions and Marimastat with matrix metalloproteinase 9.
C.K. Underwood, D. Min, J.G. Lyons and T.W. Hambley,
Journal of Inorganic Biochemistry,
2003,
95,
165-170
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The first examples of platinum amine hydroxamate complexes: structures and biological activity.
T.W. Failes, M.D. Hall, and T.W. Hambley,
Dalton Transactions,
2003,
1596-1600
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Studies of the binding of a series of platinum(IV) complexes to plasma proteins.
R.C. Dolman, G.B. Deacon and T.W. Hambley.,
Journal of Inorganic Biochemistry,
2002,
88,
260-267
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Platinum(IV) antitumour compounds: their bioinorganic chemistry.
M.D. Hall and T.W. Hambley,
Coordination Chemistry Reviews,
2002,
232,
49-67
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Platinum binding to DNA: structural controls and consequences.
T.W. Hambley.,
Journal of the Chemical Society, Dalton Transactions,
2001,
2711-2718
