Academic staff : Dr Richard Payne

Lecturer in Organic Chemistry and Chemical Biology Address: School of Chemistry, Building F11 The University of Sydney, NSW, 2006, Australia E-mail address: payne@chem.usyd.edu.au Telephone: +61-2-9351-5877 Fax: +61-2-9351-3329 Home Page: http://www.chem.usyd.edu.au/~payne

Career Profile:

• BSc (Hons, First Class) University of Canterbury, Christchurch, New Zealand. (1998-2001)
  

• Research Associate, University of Canterbury, Christchurch, New Zealand. (2001-2002)
  

• PhD (Gates Scholar), University of Cambridge (Downing College), Cambridge, UK. (2003-2006)
  

• Postdoctoral Research Associate, University of Cambridge, Cambridge, UK. (2006)
  

• Postdoctoral Research Associate (Lindemann Fellow), The Scripps Research Institute, La Jolla, California, USA. (2006-2008)
  

• Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry, 2008
  

• Lecturer, The University of Sydney, (2008 - present).
  

Areas of interest:

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include:

• Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB) and parasitic organisms e.g. Plasmodium falciparum (cause of malaria).
  

• Total synthesis of glycopeptides and glycoproteins of therapeutic interest.
  

• Development of glycopeptide-based cancer vaccines.
  
  

For current research activities and opportunities please visit our home page: http://www.chem.usyd.edu.au/~payne

Publications (2009):

1. Thordarson, P and Payne, RJ. The inaugural Australian workshop on bioconjugate chemistry, UNSW 2008. Foreward in: Aust. J. Chem., 62 (10), 1318-1319, 2009. DOI: 10.1071/CH09412
   
   
2. Chun, CKY and Payne, RJ. Synthesis of MUC1 peptide and glycopeptide dendrimers. Australian Journal of Chemistry, 62 (10), 1339-1343, 2009. DOI: 10.1071/CH09282
   
   
3. Conroy, T; Jolliffe, KA and Payne, RJ. Efficient use of the Dmab protecting group: applications for the solid-phase synthesis of N-linked glycopeptides. Organic & Biomolecular Chemistry, 7 (11), 2255-2258, 2009. DOI: 10.1039/b821051a
   
   
4. Payne, RJ; Bulloch, EMM; Toscano, MM; Jones, MA; Kerbarh, O and Abell, C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic & Biomolecular Chemistry, 7 (11), 2421-2429, 2009. DOI: 10.1039/b901694e