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Dr Richard J Payne

Lecturer

Contact Details

School of Chemistry, Building F11
The University of Sydney, NSW, 2006, Australia
E-mail address: richard.payne@sydney.edu.au
Telephone: +61-2-9351-5877
Fax: +61-2-9351-3329
Home Page: http://sydney.edu.au/science/chemistry/~payne

Career Profile

  • BSc (Hons, First Class) University of Canterbury, Christchurch, New Zealand. (1998-2001)

  • Research Associate, University of Canterbury, Christchurch, New Zealand. (2001-2002)

  • PhD (Gates Scholar), University of Cambridge (Downing College), Cambridge, UK. (2003-2006)

  • Postdoctoral Research Associate, University of Cambridge, Cambridge, UK. (2006)

  • Postdoctoral Research Associate (Lindemann Fellow), The Scripps Research Institute, La Jolla, California, USA. (2006-2008)

  • Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry, 2008

  • Lecturer, The University of Sydney, (2008 - present).


Areas of interest

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include:

  • Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB) and parasitic organisms e.g. Plasmodium falciparum (cause of malaria).

  • Total synthesis of glycopeptides and glycoproteins of therapeutic interest.

  • Development of glycopeptide-based cancer vaccines.

For current research activities and opportunities please visit our home page: http://www.chem.usyd.edu.au/~payne

Publications (2009 - 2010)

  1. Payne, RJ and Wong, C-H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chem. Commun., 46 (1), 21-43, 2010. DOI: 10.1039/b913845e

  2. Thordarson, P and Payne, RJ. The inaugural Australian workshop on bioconjugate chemistry, UNSW 2008. Foreward in: Aust. J. Chem., 62 (10), 1318-1319, 2009. DOI: 10.1071/CH09412

  3. Chun, CKY and Payne, RJ. Synthesis of MUC1 peptide and glycopeptide dendrimers. Australian Journal of Chemistry, 62 (10), 1339-1343, 2009. (invited submission for feature edition on Bioconjugate Chemistry). DOI: 10.1071/CH09282

  4. Conroy, T; Jolliffe, KA and Payne, RJ. Efficient use of the Dmab protecting group: applications for the solid-phase synthesis of N-linked glycopeptides. Organic & Biomolecular Chemistry, 7 (11), 2255-2258, 2009. DOI: 10.1039/b821051a

  5. Payne, RJ; Bulloch, EMM; Toscano, MM; Jones, MA; Kerbarh, O and Abell, C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic & Biomolecular Chemistry, 7 (11), 2421-2429, 2009. DOI: 10.1039/b901694e

  6. Garner, J; Jolliffe, KA; Harding, MM and Payne, RJ. Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy. Chem. Commun., (45), 6925-6927, 2009. DOI: 10.1039/b918021d

  7. Thomas, GL and Payne, RJ. Phosphate-assisted ligation. Chem. Commun., (28), 4260-4262, 2009. DOI: 10.1039/b906492c Highlighted in meet our authors section: http://www.rsc.org/Publishing/Journals/cc/People/authors/Richard_Payne.asp

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