Academic staff : Dr Richard Payne

Lecturer in Organic Chemistry and Chemical Biology

Address:
School of Chemistry, Building F11
The University of Sydney, NSW, 2006, Australia
E-mail address: payne@chem.usyd.edu.au
Telephone: +61-2-9351-5877
Fax: +61-2-9351-3329
Home Page: http://www.chem.usyd.edu.au/~payne

Career Profile:

  • BSc (Hons, First Class) University of Canterbury, Christchurch, New Zealand. (1998-2001)

  • Research Associate, University of Canterbury, Christchurch, New Zealand. (2001-2002)

  • PhD (Gates Scholar), University of Cambridge (Downing College), Cambridge, UK. (2003-2006)

  • Postdoctoral Research Associate, University of Cambridge, Cambridge, UK. (2006)

  • Postdoctoral Research Associate (Lindemann Fellow), The Scripps Research Institute, La Jolla, California, USA. (2006-2008)

  • Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry, 2008

  • Lecturer, The University of Sydney, (2008 - present).


Areas of interest:

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include:

  • Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB) and parasitic organisms e.g. Plasmodium falciparum (cause of malaria).

  • Total synthesis of glycopeptides and glycoproteins of therapeutic interest.

  • Development of glycopeptide-based cancer vaccines.

For current research activities and opportunities please visit our home page: http://www.chem.usyd.edu.au/~payne


Publications (2009):

1. Payne, R. J.; Wong, C-H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chem. Commun., DOI:10.1039/b913845e
http://www.rsc.org/Publishing/Journals/CC/article.asp?doi=b913845e

2. Garner, J.; Jolliffe, K. A.; Harding, M. M.; Payne, R. J. Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy. Chem. Commun., 2009, 6925-6927.
http://www.rsc.org/Publishing/Journals/CC/article.asp?doi=b918021d 

3. Thomas, G. L.; Payne, R. J. Phosphate-assisted ligation. Chem. Commun. 2009, 4260-4262.
http://www.rsc.org/Publishing/Journals/CC/article.asp?doi=b906492c

Highlighted in meet our authors section:

http://www.rsc.org/Publishing/Journals/cc/People/authors/Richard_Payne.asp

4. Chun, C. K. Y.; Payne, R. J. Synthesis of MUC1 peptide and glycopeptide dendrimers. Aust. J. Chem. 2009, 1339-1343 (invited submission for feature edition on Bioconjugate Chemistry).
http://www.publish.csiro.au/nid/51/paper/CH09282.htm

5. Conroy, T.; Jolliffe, K. A.; Payne, R. J. Efficient use of the Dmab protecting group: applications for the solid-phase synthesis of N-linked glycopeptides. Org. Biomol. Chem. 2009, 2255-2258.
http://www.rsc.org/Publishing/Journals/OB/article.asp?doi=b821051a 

6. Payne, R. J.; Bulloch, E. M. M.; Toscano, M. M.; Jones, M. A.; Kerbarh, O.; Abell, C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes, Org. Biomol. Chem. 2009, 7, 2421-2429.
http://www.rsc.org/Publishing/Journals/OB/article.asp?doi=b901694e

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